The Ultimate Pianist Lab (超高校級のピアニストの研究教室) was first found in Chapter 1. It is located on the Academy's first floor in front of the classrooms. There is a grand piano inside, completed with different musical scores and DVDs on the big self on the wall. There is also a blackboard behind the piano. This lab belongs to Kaede Akamatsu.
During the first portion of Chapter 1, the lab is locked as Monokuma is still preparing it. But at some point, it becomes available for Kaede to explore. At the end of Chapter 1, following Kaede's execution, Shuichi Saihara listens to Claude Debussy's Clair de Lune inside it while imagining Kaede playing the piano.
Miu Iruma's Lab
The Ultimate Inventor Lab (超高校級の発明家の研究教室) was unlocked in Chapter 1, though the player cannot enter it until Chapter 2. It is located outside the school building, near the Shrine of Judgement. It is packed with large, dangerous looking tools such as chainsaws and drills that hang from the ceiling, as well as what appears to be a bed to perform experiments on, and tables that hold chemicals. There is also large screens on the back wall and fancy looking chairs and couches. This lab belongs to Miu Iruma.
During the first half of Chapter 1, the lab is locked as Monokuma is still preparing it. Later in the chapter, Miu spends most of her time inside, working on the cameras that Kaede and Shuichi asked her to make.
Himiko Yumeno's Lab
The Ultimate Magician Lab (超高校級のマジシャンの研究教室), belonging to Himiko Yumeno, was first found in Chapter 2, after the hallway leading up to it was opened. It is located on the ground floor of the academy. The door to it is blue, with a magical insignia inscribed on it. Inside the lab, there is a brewing pot in the center, which Himiko says she stores her Mana in, a guillotine, a cage with four doves in it, and multiple contraptions meant to show during a magical show.
Kirumi Tojo's Lab
The Ultimate Maid Lab (超高校級のメイドの研究教室) was first found in Chapter 2, after the passageway in the second floor is opened up. It is decorated in a Victorian style, which was the time when owning a maid was considered to show royalty, as said by the lab's owner, Kirumi Tojo.
Gonta Gokuhara's Lab
The Ultimate Entomologist Lab (超高校級の昆虫博士の研究教室) is found during Chapter 2, after a hallway in the second floor is opened up. The door to the lab is decorated with a butterfly. The room itself is full of greenery and has its walls lined with small terrariums for insects. This lab belongs to Gonta Gokuhara.
In order to host a "viewing party" for everyone's motive videos, Kokichi makes Gonta kidnap everyone and bring them to his Research Lab. Shuichi was kidnapped while he was talking to Ryoma. Ryoma apologizes to Shuichi before running away, while Gonta manages to knock Shuichi into unconsciousness. He later finds himself stuck in the lab with Kokichi sitting on top of him. Along with him, Gonta managed to kidnap K1-B0, Korekiyo, Tenko and Tsumugi, giving them all alibis during the middle part of the second class trial.
Ryoma Hoshi's Lab
The Ultimate Tennis Pro Lab (超高校級のテニス選手の研究教室) was first found in Chapter 2, after the passageway in the second floor is opened up. It is located on the third floor of the academy. The room itself has a tennis field and a backroom, containing showers. The room also contains handcuffs in the shower room, symbolising the owner, Ryoma's, past as a prisoner. The room has a window that overlooks the pool and is parallel to the back of the gym.
During the second chapter, this lab is where the murder of the Ryoma himself takes place. Kirumi Tojo shows her motive to Ryoma, asking for help. Ryoma, after telling her that her life means a lot more than his, looks away from her, giving her a chance to strike him in the head, knocking him out. She then handcuffs him using the handcuffs found in the lab and uses the sinks in the shower room in the back of the lab to drown him, killing him. As the lab and gym are parallel to each other, Kirumi uses the window to make a make-shift way to the gym without breaking the schools rules and dumps his body in the piranha tank.
Maki Harukawa's Lab
The Ultimate Assassin Lab (超高校級の暗殺者の研究教室), initially thought to be the Ultimate Child Caregiver Lab, is first found in Chapter 2, but the owner, Maki, refuses to let anyone in until the beginning of Chapter 3. It is located on the third floor of the academy. The door is decorated in red. During Chapter 2, Maki barricades herself inside and refuses to let anyone in, in order to keep her true talent a secret. This leads to her not having an alibi during the Class Trial. After the class trial in Chapter 2, Maki's secret is revealed to everyone after Kokichi tells everyone about it, despite Maki's attempt to stop him.
Tenko Chabashira's Lab
The Ultimate Aikido Master Lab (超高校級の合気道家の研究教室) is first found in Chapter 3. This lab belongs to Tenko Chabashira. It is located in the courtyard, next to the Shrine of Judgement. It's a large and spacious dojo with several platforms hanging by chains to the ceiling, and several automated-moving practice dummies to spar with. A large purple banner hangs in the middle with a logo resembling the patterns in Tenko's bow. In Chapter 4, Himiko, Gonta, and Shuichi practice Aikido in a bonus event after her death to honor her.
Korekiyo Shinguji's Lab
The Ultimate Anthropologist Lab (超高校級の民俗学者の研究教室) is first found in Chapter 3. It is located on the fourth floor of the academy. It is rather large compared to the other Research Labs. It has around five floors total, various historical items on display in glass cases, on the walls, or on tables. Paintings adorn the walls too, presumably much older pieces of artwork. This lab belongs to Korekiyo Shinguji.
Angie Yonaga's Lab
The Ultimate Artist Lab (超高校級の美術部の研究教室) is first found in Chapter 3. This lab belongs to Angie Yonaga, and is where she was murdered by Korekiyo Shinguji. It is located on the fourth floor of the academy. It is almost entirely white, save for the large splatters of paint scattered here and there, and dimly lit. It has several crafting tables, blank canvases and multiple buckets of paint and brushes all over the floor. The ceiling beams are also exposed, and it has a backdoor with a switch lock.
The Ultimate Robot Lab (超高校級のロボットの研究教室) is first found in Chapter 4. This lab belongs to K1-B0. It is located in the courtyard and is connected to Miu Iruma's lab. It is chock full of a futuristic sci-fi aesthetic. It is primarily blue, with glowing lights from cyan to a bright yellow. There are hologram screens depicting unknown information and a station to repair or upgrade K1-B0 at a given moment. Machinery is the main point of his lab, and for this K1-B0 prefers not to bother using any of the things in there, until Chapter 6 at least when he loses his antenna, deciding to destroy the school.
Tsumugi Shirogane's Lab
The Ultimate Cosplayer Lab (超高校級のコスプレイヤーの研究教室) is first found in Chapter 4. This lab belongs to Tsumugi Shirogane. It is located on the fifth floor of the academy. Her lab is a large warehouse lacking any color, with several stage sets for cosplaying in swapping at the back. She has a set for a bar, and a darkly colored one with a couch. Lights and cameras are facing the switching sets in the back, and she has two cosplay outfits out in the open.
Shuichi Saihara's Lab
The Ultimate Detective Lab (超高校級の探偵の研究教室) is first found in Chapter 4. This lab belongs to Shuichi Saihara and is located on the fifth floor of the academy. It has a rustic, old-fashioned feel to it. A rocking chair is sat nearby a burning fireplace, and a work desk with scientific equipment and books stacked on top. Present is a large cabinet full of poisons and various other things, along with a hat rack, showcasing several bowler hats. Furthermore, his room contains a bookshelf with files detailing presumably every murder in all Danganronpa series to the 52nd, as "the newer files have photographs, but the older ones have illustrations."
Kaito Momota's Lab
The Ultimate Astronaut Lab (超高校級の宇宙飛行士の研究教室) was first found in Chapter 5. This lab belongs to Kaito Momota. The entrance to his lab is located on the first floor; however a very long spiral staircase is needed to access it. It resembles a simulation for being inside a spaceship, with a control panel in the middle. Hidden behind one of the walls is the room where the participants in The Gofer Project supposedly spent centuries in cold sleep.
Rantaro Amami's Lab
The Ultimate Survivor Lab (超高校級の生存者の研究室) is first found in Chapter 5, but remains locked until the investigation section of Chapter 6. This lab belongs to Rantaro Amami and is located on the fifth floor of the academy, near Shuichi's lab. His lab is large and red, roses decorating the span of the floor, with a large round table in the middle, several unconventional chairs surrounding it which resembles a Class Trials room, possibly referencing the fact he already was a participant in one killing game. A large two-part safe is in the back, where you have to open it in Chapter 6 with the clues left behind. The entire area is in disarray, obfuscating the purpose and meaning of his talent.
Kokichi Oma's Lab
The Ultimate Supreme Leader Lab (超高校級の総統の研究教室) is first found in Chapter 6. It is located underground. It resembles a supervillain's lair, inhabiting various faux weaponry used for pranks, like handcuffs, empty suitcases, gas masks, and two-way radios. A few clown masks are also seen lying around, a large replica of a helicopter hanging from the ceiling, a car resembling a Batmobile, and a very prominent throne, the D.I.C.E. logo above. This lab belongs to Kokichi Oma.